PREIMPLANTATION GENETIC TESTING FOR ANEUPLOIDY (PGT-A)

PGTA Centre in Shaikpet

PGT-A or Preimplantation Genetic Testing for Aneuploidy, formerly known as PGS, is a test provided at PGTA Centre in Shaikpet used to screen embryos for aneuploidies or an abnormal number of chromosomes in a cell, prior to transfer into the uterus with a goal to increase the chance of achieving a successful pregnancy.
Chromosomal abnormalities can occur in women of any age but usually seen in older women and these abnormalities are one of the main causes for implantation failure in IVF cases requiring PGT-A test at PGTA center in Shaikpet.

PGTA Centre in Shaikpet

HOW’S IT DONE?
During an IVF cycle, the patient’s embryos are evaluated for biopsy.
During the biopsy, a single cell or multiple cells are removed from the embryo. Following the biopsy, the remaining embryos are cryopreserved and the testing is performed on the biopsied cells.
After screening, the viable embryos are then transferred into the uterus or preserved for future fertility treatment.

PGTA Treatment in Shaikpet
PGTA Treatment in Shaikpet
Preimplantation Genetic Screening
WHO IS THIS FOR?
The Pre-implantation Genetic Screening test is ideal for couples whom:

• Have Suffered  miscarriage
• Had several failed IVF cycles
• Had repeated implantation failures
• Are undergoing an IVF treatment for the first time
Pre-implantation genetic testing for aneuploidy has the potential to:
• Boost the IVF birth rate per transferred embryo.
• Reduce the amount of miscarriages and birth abnormalities caused by chromosomal number irregularities in eggs.
• Lower the number of multiple pregnancies while keeping the live birth rate high.

PGT-A is currently mostly done on day five or six of the blastocyst stage. There is no evidence from randomized controlled trials or RCTs that PGT-A performed at this time improves the likelihood of having a baby for the majority of IVF participants. It is possible that the lower supply of embryos for transfer after PGT-A will cancel out any embryo selection benefits. There have been no RCTs undertaken with the primary goal of determining the impact of PGT-A on the rate of miscarriage. PGT-A may be advantageous for certain types of women, particularly older women, in terms of a potential reduction in miscarriage, according to some data.

FAQs

PGT-A results have shown:

  • To increase implantation rates
  • To a reduced number of miscarriage rates
  • To increase live birth rates
  • To enable confident single embryo transfer 

This simple procedure utilises the biopsied embryos that are sent to our lab and process using sophisticated technology to analyse the material present within each embryo. After a thorough assessment, the chosen embryos are then implanted into the uterus. Embryos with the correct number of chromosomes often lead to a healthy and successful pregnancy.

Yes, some patients may have to undergo multiple IVF cycles in order to produce a chromosomally normal embryo for transfer. There may also be a slight chance in damage to the embryo during the biopsy. Additionally, they will have to be frozen while PGT-A is performed and must be thawed prior to transfer. This may affect the survival rate of the embryos that were frozen and then thawed.

PGT-A tests are not used to detect specific genetic disorders or syndromes. PGT-M tests on the other hand are used for such a purpose to identify and eliminate specific genetic mutations from the parent to the offspring.