PREIMPLANTATION GENETIC TESTING FOR MONOGENIC DISORDERS (PGT-M)

PGTM Centre in Shaikpet

PGT-M or Preimplantation Genetic Testing for Monogenic Disorders, formerly known as PGD, is a technique used at PGTM Centre in Shaikpet to screen embryos to identify specific heritable diseases or genetic disorders. This is used in conjunction with IVF at PGTM Centre in Shaikpet, where embryos are first screened before being implanted into the uterus.

HOW IS IT DONE?
• During an IVF cycle, the patient’s embryos are evaluated for biopsy.
• During the biopsy, a single cell or multiple cells are removed from the embryo. Following the biopsy, the remaining embryos are cryopreserved and the testing is performed on the biopsied cells.
• After screening, the viable embryos are then transferred into the uterus or preserved for future fertility treatment. Karyomapping-  A technique for achieving PGT-M. The formulation of a unique custom-made testing plan and mapping platform for each pair is part of the PGT-M preparation process with Karyomapping. The embryos that are afflicted and unaffected by the genetic disease being tested for will then be detected.

PGTM Centre in Shaikpet

WHO IS THIS FOR?
Pre-implantation Genetic Diagnosis
This Pre-implantation Genetic Diagnosis test is ideal for the following kinds of patients:
• One or both partners carry a heritable disease or genetic disorders such as Cystic Fibrosis, Thalassemia, and Spinal Muscular Atrophy.
• One or both partners are carriers of a specific kind of chromosomal abnormality
This test may be useful for couples who:
• Have or had a child with a heritable disease
• Have had a pregnancy loss due to a heritable disease
• Have a family history of heritable disease

Preimplantation genetic diagnosis (PGD) was created for patients who are at high risk of passing on a defective gene to their children, including all monogenic problems (autosomal recessive, autosomal dominant and X-linked disorders). As a result, carrier testing of parents for monogenic disorders through embryonic diagnosis before or during pregnancy can help individuals have healthy children, and it is an effective strategy to realize  parental reproductive health and control the occurrence of monogenic disease in future offspring.
Pre-implantation Genetic Diagnosis

FAQs

In addition to the biopsied cells from the embryos, the lab conducting the testing may also require blood samples, saliva or in some cases sperm samples from the male partner depending on the evaluation of the case.

Yes, however, they will need to be evaluated first by our genetic counselor to determine if the samples provided are viable before proceeding with the test as each case is unique.

Yes, there may be a slight chance of damage to the embryo during the biopsy. Additionally, they will have to be frozen while PGT-M is performed and must be thawed prior to transfer. This may affect the survival rate of the embryos that were frozen and then thawed.

After receiving the relevant samples including DNA samples such as blood or saliva, the process could take about 8 to 12 weeks. The process must be fully completed before moving on to the IVF cycle.